The cheapest option is leaving your car in one of the car parks in front of Mestre station (the city just before Venice) then cross the street and take the first train from Mestre to Venice Santa Lucia (they are frequent and you will arrive in Venice in just 10 minutes).
The car park on the island of Tronchetto is immediately after the Ponte della Libertà which connects the mainland to Venice. They do not take reservations but you can easily check availability on the site: https://www.tronchettoparking.it
The most convenient option is parking the car in one of the parks in Piazzale Roma (bus and vaporetto terminal): it is the extreme point that can be reached by car.
In this case we recommend Autorimessa Comunale or Garage San Marco.
In both cases it is better to call and take a reservation:
Autorimessa Comunale +39 41 2727301
Garage San Marco +39 41 5232213
FROM PIAZZALE ROMA:
Once reached Piazzale Roma by car or bus, simply get to the water-side of the Grand Canal where you will find the ticket office and the various vaporetto stops. You can think about the possibility of buying the ticket for 24/48/72 hours, depending on your plans.
More info: https://actv.avmspa.it/it/content/vaporetto
The vaporetto to take is line #1. This is the only line that stops at Rialto Mercato (the sixth stop and closest to the b&b). Once you get off at the Rialto Mercato stop, turn right and cross the fruit and fish market, always keeping the Grand Canal on your right. Cross the small bridge that you find on the water side and you will arrive in Riva dell’Ogio, after a few meters you will find Calle dei Botteri on the left.
Our address is Calle dei Botteri 1569 ( in case you want to help yourself with Google Maps once you get off at Rialto Mercato).